Immunolocalization of elastase in human emphysematous lungs.
نویسندگان
چکیده
منابع مشابه
Immunolocalization of elastase in human emphysematous lungs.
The current working hypothesis concerning the pathogenesis of human pulmonary emphysema proposes that neutrophils migrate through the alveolar interstitium and degranulate, releasing proteolytic enzymes into the interstitium. These enzymes, in particular elastase, can bind to and degrade interstitial elastin. This report describes an immunohistochemical, ultrastructural technique that utilizes ...
متن کاملCollagen content of alveolar wall tissue in emphysematous and non-emphysematous lungs.
BACKGROUND Emphysema is currently defined as "a condition of the lung characterised by abnormal, permanent enlargement of the airspaces distal to the terminal bronchiole, accompanied by destruction of their walls, and without obvious fibrosis." The functional and morphological changes that occur in emphysema have largely been attributed to changes in alveolar elastin rather than in collagen. A ...
متن کاملLong-range diffusion of hyperpolarized 3He in explanted normal and emphysematous human lungs via magnetization tagging.
Long-range diffusivity of hyperpolarized 3He gas was measured from the decay rate of sinusoidally modulated longitudinal nuclear magnetization in three normal donor and nine severely emphysematous explanted human lungs. This (long-range) diffusivity, which we call Dsec, is measured over seconds and centimeters and is approximately 10 times smaller in healthy lungs (0.022 cm2/s) than the more tr...
متن کاملLong-range diffusion of hyperpolarized He in explanted normal and emphysematous human lungs via magnetization tagging
Woods, Jason C., Dmitriy A. Yablonskiy, Cliff K. Choong, Kimiaki Chino, John A. Pierce, James C. Hogg, John Bentley, Joel D. Cooper, Mark S. Conradi, and Peter T. Macklem. Long-range diffusion of hyperpolarized He in explanted normal and emphysematous human lungs via magnetization tagging. J Appl Physiol 99: 1992–1997, 2005. First published July 14, 2005; doi:10.1152/japplphysiol.00185.2005.—Lo...
متن کاملInnovative Methodology Long-range diffusion of hyperpolarized He in explanted normal and emphysematous human lungs via magnetization tagging
Woods, Jason C., Dmitriy A. Yablonskiy, Cliff K. Choong, Kimiaki Chino, John A. Pierce, James C. Hogg, John Bentley, Joel D. Cooper, Mark S. Conradi, and Peter T. Macklem. Long-range diffusion of hyperpolarized He in explanted normal and emphysematous human lungs via magnetization tagging. J Appl Physiol 99: 1992–1997, 2005. First published July 14, 2005; doi:10.1152/japplphysiol.00185.2005.—Lo...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1986
ISSN: 0021-9738
DOI: 10.1172/jci112600